Mobola plum seed methanolic extracts exhibit mixed type inhibition of angiotensin -converting enzyme in vitro

Author: Olamide Olajusi CROWN ¹ ; Olanrewaju Sam OLAYERIJU ¹ ; Ayodele Oluwaseyi KOLAWOLE ¹ ; Afolabi Clement AKINMOLADUN ¹ ; Mary Tolulope OLALEYE ¹ ; Afolabi Akintunde AKINDAHUNSI ¹
Author Information

1. Department of Biochemistry, the Federal University of Technology
Publication Type:Journal Article
Keywords: Angiotensin converting enzyme; Blood pressure; FAPGG; Mixed type inhibition; Parinari curatellifolia
From:Asian Pacific Journal of Tropical Biomedicine 2017;7(12):1079-1084
CountryChina
Language:Chinese
Abstract: Objective To explore the possible inhibitory potentials and mechanism by Mobola plum (Parinari curatellifolia) seeds crude methanol (CE) and flavonoid-rich (FE) extracts on angiotensin-1-converting enzyme (ACE ). Methods The sensitivity and kinetic model of inhibition of CE and FE on ACE using N-[3-(2-furyl)-acryloyl]-Phe-Gly-Gly as enzyme substrate for ACE was evaluated by Michealis Menten approach. The inhibition mechanism was explored from Lineweaver–Burk model and IC