Bioactive compounds fractionated from endophyte Streptomyces SUK 08 with promising ex-vivo antimalarial activity
10.1016/j.apjtb.2017.10.006
- Author:
Noraziah Mohamad ZIN
1
;
Juwairiah REMALI
1
;
Mohd Nazir NASROM
1
;
Shafariatul Akmar ISHAK
1
;
Mohd Shukri BABA
2
;
Juriyati JALIL
3
Author Information
1. School of Diagnostic Sciences and Applied Health, Faculty of Health Sciences, Universiti Kebangsaan Malaysia
2. Department of Biomedical Science, Kulliyyah of Allied Health Science, International Islamic University Malaysia
3. Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia
- Publication Type:Journal Article
- Keywords:
2,3-Heptanedione;
Antimalarial;
Butyl–propyl–ester;
Cyclohexane;
Endophyte;
Streptomyces
- From:Asian Pacific Journal of Tropical Biomedicine
2017;7(12):1062-1066
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine ex vivo antimalarial activity and cytotoxicity of endophytic Streptomyces SUK 08 as well as the main core structure fractionated from its crude extract. Methods The activities of SUK 08 crude extract were evaluated by using the Plasmodium lactate dehydrogenase assay and synchronization test against rodent malaria parasite Plasmodium berghei, instead of human malarial parasite Plasmodium falciparum. The cytotoxicity of the crude extract was determined by MTT assay. The crude extract was analyzed by thin-layer chromatography and gas chromatography–mass spectrophotometry. Results The ethyl acetate crude extract showed very promising antimalarial activity with IC
