Identification of commonly regulated protein targets and molecular pathways in PC-3 and DU145 androgen-independent human prostate cancer cells treated with the curcumin analogue 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one

Author: Kamini CITALINGAM ¹ ; Iekhsan OTHMAN ¹ ; Rakesh NAIDU ¹ ; Faridah ABAS ² ; Nordin H. LAJIS ² ; Faridah ABAS ³
Author Information

1. Jeffery Cheah School of Medicine and Health Sciences, Monash University Malaysia
2. Laboratory of Natural Products, Faculty of Science, Universiti Putra Malaysia
3. Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia
Publication Type:Journal Article
Keywords: Androgen-independent prostate cancer; Diarylpentanoid; Mass spectrometry; Pathway analysis; Proteomics profiling
From:Asian Pacific Journal of Tropical Biomedicine 2018;8(9):436-445
CountryChina
Language:Chinese
Abstract: Objective: To identify mutually regulated proteins in PC-3 and DU145 androgen-independent prostate cancer cell lines treated with 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one (MS17), and to study the molecular pathways that contributed to the anticancer activity of MS17. Methods: PC-3 and DU145 cells were treated with 3 × EC