Identification of commonly regulated genes in HPV18- and HPV16-infected cervical cancer cells treated with the curcumin analogue 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one

Author: Felicia PAULRAJ ¹ ; Iekhsan OTHMAN ¹ ; Sharifah HASSAN ¹ ; Rakesh NAIDU ¹ ; Faridah ABAS ² ; Nordin LAJIS ² ; Faridah ABAS ³
Author Information

1. Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia
2. Laboratory of Natural Products, Faculty of Science, Universiti Putra Malaysia
3. Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, UPM Serdang
Publication Type:Journal Article
Keywords: Cervical cancer; Curcumin analogue; Diarylpentanoid; Gene expression profiling; Microarray
From:Asian Pacific Journal of Tropical Biomedicine 2018;7(1):44-51
CountryChina
Language:Chinese
Abstract: Objective: To identify commonly regulated genes in HPV-infected HeLa and CaSki cervical cancer cells treated with curcumin analogue 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one (MS17) and to explore potential mechanisms that underlie its cytotoxic, anti-proliferative and apoptotic activity. Methods: HeLa and CaSki cells were treated with 2 × EC