Insight into DNA protection ability of medicinal herbs and potential mechanisms in hydrogen peroxide damages model

Author: Zahra SABAHI ¹ ; Mahmoodreza MOEIN ¹ ; Fatemeh SOLTANI ² ; Mahmoodreza MOEIN ³
Author Information

1. Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences
2. Biotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences
3. Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences
Publication Type:Journal Article
Keywords: Comet assay; DNA damage; Herbal medicine; Hydrogen peroxide; Single cell gel electrophoresis
From:Asian Pacific Journal of Tropical Biomedicine 2018;8(2):120-129
CountryChina
Language:Chinese
Abstract: DNA damage is one of the most important consequences of oxidative stress in the cells. If DNA repair is unable to modify these inducible DNA damages, genomic instability may lead to mutation, cancer, aging and many other diseases. Single cell gel electrophoresis or comet assay is a common and versatile method to quantify these types of DNA damages. DNA damages induced by hydrogen peroxide (H