Antidiabetic potential of methanol extracts from leaves of Piper umbellatum L. and Persea americana Mill.

Guy Sedar Singor Njateng; Larissa Chimi; Cesaire Feudjio; Donatien Gatsing; Jules-roger Kuiate; Guy Sedar Singor Njateng; Sumera Zaib; Ezekiel Adewole; Jamshed Iqbal; Raymond Simplice Mouokeu; Ezekiel Adewole

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Antidiabetic potential of methanol extracts from leaves of Piper umbellatum L. and Persea americana Mill.

Author: Guy Sedar Singor NJATENG ¹ ; Larissa CHIMI ¹ ; Cesaire FEUDJIO ¹ ; Donatien GATSING ¹ ; Jules-Roger KUIATE ¹ ; Guy Sedar Singor NJATENG ² ; Sumera ZAIB ² ; Ezekiel ADEWOLE ² ; Jamshed IQBAL ² ; Raymond Simplice MOUOKEU ³ ; Ezekiel ADEWOLE ⁴
Author Information

1. Laboratory of Microbiology and Antimicrobial Substances, Faculty of Science, University of Dschang
2. Centre for Advanced Drug Research, COMSATS Institute of Information Technology
3. Institute of Fisheries and Aquatic Sciences, University of Douala
4. Department of Chemical Sciences, Afe Babalola University Ado
Publication Type:Journal Article
Keywords: Aldehyde reductase; Aldose reductase; Glucosidase; Maltase-glucoamylase; Persea americana; Piper umbellatum
From:Asian Pacific Journal of Tropical Biomedicine 2018;8(3):160-165
CountryChina
Language:Chinese
Abstract: Objective: To determine inhibitory activity of methanolic leaf extract of Piper umbellatum and Persea americana (P. americana) (traditionally used in Cameroon against diabetes) on α-glucosidase, β-glucosidase, maltase-glucoamylase, aldose reductase and aldehyde reductase activities, enzymes involved in starch digestion or diabetic complications. Methods: The methanol extracts from Piper umbellatum and P. americana were prepared by maceration. To assess relative efficacy of these extracts, the determination of concentrations that were needed to inhibit 50% of enzyme activity was done, whereas, gas chromatography-mass spectrum was used to identify components from extracts that may be responsible for the activities. Results: The tested extracts strongly inhibited α-glucosidase, maltase-glucoamylase, aldose reductase and aldehyde reductase activities with IC