NO-cGMP-K channel-dependent anti-nociceptive activities of methanol stem bark extract of Piptadeniastrum africanum (Mimosaceae) on rats
- Author:
Mbiantcha MARIUS
1
;
Ateufack GILBERT
1
;
Bomba Tatsinkou Francis DESIRE
1
;
Almas JABEEN
2
;
Nida DASTAGIR
2
;
Shabana U. SIMJEE
3
Author Information
- Publication Type:Journal Article
- Keywords: cGMP; Inflammatory pain; Neuropathic pain; Nitric oxide; Piptadeniastrum africanum
- From:Asian Pacific Journal of Tropical Biomedicine 2018;8(3):150-159
- CountryChina
- Language:Chinese
- Abstract: Objective: To explore anti-hyperalgesic properties of methanol extract of Piptadeniastrum africanum stem bark (PAME) and it possible action mechanism. Methods: PAME was tested on carrageenan induced hyperalgesia using plantar test (thermal) and analgesymeter (mechanical) in rats, on prostaglandin E