Physicochemical properties, antioxidant and anti-inflammatory activities of coumarin-carbonodithioate hybrids

Author: Suresh KUMBAR ¹ ; Kallappa HOSAMANI ¹ ; Arun SHETTAR ²
Author Information

1. Department of Studies in Chemistry, Karnatak University
2. P G Department of Studies in Biotechnology and Microbiology, Karnatak University
Publication Type:Journal Article
Keywords: Coumarin-carbonodithioates; In vitro anti-inflammatory activity; In vitro antioxidant activity; Physicochemical properties
From:Asian Pacific Journal of Tropical Biomedicine 2018;8(4):201-206
CountryChina
Language:Chinese
Abstract: Objective: To study physicochemical properties, antioxidant and anti-inflammatory activities of coumarin-carbonodithioate hybrids. Methods: The substituted 4-bromomethyl coumarins were synthesized in first step by the cyclization. Then the reaction of substituted coumarins (a-e) with potassium O-ethyl/methyl carbonodithioate (1) by using absolute ethanol as solvent, afforded coumarin-carbonodithioate (1a-1j) derivatives under microwave irradiation and the conventional method. The spectroscopic analysis was used for the characterization of coumarin derivatives. The title (1a-1j) compounds were confirmed by spectroscopic methods. Antioxidant property was evaluated by using DPPH free radical-scavenging ability assay method and anti-inflammatory activity was evaluated by protein denaturation procedure using diclofenac sodium as a standard. Drug-likeness. In-silico toxicity was predicted with LD