Anti-epileptic effect of morin against experimental pentylenetetrazol-induced seizures via modulating brain monoamines and oxidative stress
- Author:
Amit D. KANDHARE
1
;
Anwesha A. MUKHERJEE
1
;
Subhash L. BODHANKAR
1
Author Information
- Publication Type:Journal Article
- Keywords: Brain GABA; Epilepsy; Morin; Nitric oxide; Oxidative stress; Pentylenetetrazol; Xanthine oxidase
- From:Asian Pacific Journal of Tropical Biomedicine 2018;8(7):352-359
- CountryChina
- Language:Chinese
- Abstract: Objective: To evaluate the protective effect of morin against pentylenetetrazol (PTZ)-induced tonic-clonic convulsions in mice. Methods: Swiss albino mice (18-22 g) was used to induce convulsions by intraperitoneal (i.p.) administration of PTZ (90 mg/kg). Mice were either pretreated with morin (10, 20 and 40 mg/kg) or vehicle (distilled water, 10 mg/kg) 45 min before PTZ administration. Various behavioral and biochemical parameters were assessed. Results: PTZ administration resulted in significant production (P<0.001) of tonic-clonic conclusion and mortality in mice. PTZ-induced increase in the duration of convulsion, onset of convulsion and mortality was inhibited significantly by morin (20 and 40 mg/kg) administration. The PTZ-induced decrease in brain GABA, dopamine and Na
