Anti-quorum sensing and anti-biofilm formation activities of plant extracts from South Korea

Okhee Choi; Jinwoo Kim; Dong-wan Kang; Su Cho; Yeyeong Lee; Seunghoe Kim; Byeongsam Kang; Juyoung Bae; Jinwoo Kim; Jeong Hoon Lee; Seung Eun Lee

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Anti-quorum sensing and anti-biofilm formation activities of plant extracts from South Korea

Author: Okhee CHOI ¹ ; Jinwoo KIM ¹ ; Dong-Wan KANG ² ; Su CHO ³ ; Yeyeong LEE ³ ; Seunghoe KIM ³ ; Byeongsam KANG ⁴ ; Juyoung BAE ⁴ ; Jinwoo KIM ⁴ ; Jeong Hoon LEE ⁵ ; Seung Eun LEE ⁵
Author Information

1. Institute of Agriculture and Life Science, Division of Applied Life Science, Gyeongsang National University
2. Gyeonsangnam-do Agriculture Extension Services
3. Department of Plant Medicine, Gyeongsang National University
4. Division of Applied Life Science, Gyeongsang National University
5. National Institute of Horticultural and Herbal Science, Rural Development Administration
Publication Type:Journal Article
Keywords: Biofilm formation; Cornus controversa; Plant extracts; Quorum sensing
From:Asian Pacific Journal of Tropical Biomedicine 2018;8(8):411-417
CountryChina
Language:Chinese
Abstract: Objective: To investigate anti-quorum sensing (anti-QS) and anti-biofilm formation (anti- BF) activities of the ethanol extracts of 388 plants. Methods: The anti-QS activity of the plant extracts was evaluated by disc-diffusion assays using the bio-reporter strain, Chromobacterium violaceum CV017. Pseudomonas aeruginosa PAO1, Yersinia enterocolitica ATCC 9610, and Agrobacterium tumefaciens C58, which possess QS systems, were used to evaluate the anti- BF activity of the plant extracts. Results: Among 388 plant extracts, the Cornus controversa (C. controversa) and Cynanchum wilfordii extracts exhibited the strongest anti-QS activity. The C. controversa extract exhibited anti-BF activity against Pseudomonas aeruginosa, Yersinia enterocolitica and Agrobacterium tumefaciens, whereas the Cynanchum wilfordii extract exhibited no anti-BF activity against Pseudomonas aeruginosa. In addition, the C. controversa extract suppressed soft rot of cabbage. Conclusions: The C. controversa extract inhibits bacterial QS and BF, and is capable of controlling soft rot. Therefore, this extract has potential for the prevention and treatment of bacterial infections and for the development of alternatives to antibiotics.