Anti-cancer effects of hydro-alcoholic extract of pericarp of pistachio fruits

Hamidreza Harandi; Ahmad Majd; Soudeh Khanamani Falahati-pour; Mehdi Mahmoodi; Mehdi Mahmoodi

Return

Anti-cancer effects of hydro-alcoholic extract of pericarp of pistachio fruits

Author: Hamidreza HARANDI ¹ ; Ahmad MAJD ² ; Soudeh Khanamani FALAHATI-POUR ³ ; Mehdi MAHMOODI ⁴ ; Mehdi MAHMOODI ⁵
Author Information

1. Department of Biochemistry, North Tehran Branch, Islamic Azad University
2. Department of Biology, Faculty of Science, Tehran North Branch, Islamic Azad University
3. Pistachio Safety Research Center, Rafsanjan University of Medical Sciences
4. Department of Clinical Biochemistry, Afzalipoor Faculty of Medicine, Kerman University of Medical Sciences
5. Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences
Publication Type:Journal Article
Keywords: Apoptosis; Cytotoxicity; Gene expression; Pistacia vera
From:Asian Pacific Journal of Tropical Biomedicine 2018;8(12):598-603
CountryChina
Language:Chinese
Abstract: Objective: To investigate the cytotoxicity and anti-cancer effects of hydro-alcoholic extract of pistachio pericarp on hepatocellular carcinoma cells (HepG2) and mouse fibroblast L929 cells as normal and control group cell. Methods: MTT assay was performed to investigate the cytotoxicity effects of the extract at 0-4 000 μg/mL on the cells after 24 and 48 h. The expressions of some genes involved in apoptosis including Bax, Bcl-2 and P53 were investigated by real time PCR. Results: Our results showed that after 24 and 48 hours of treatment of cells with this extract, the viability of HepG2 and L929 cells was reduced. Therefore, this extract had the cytotoxicity effect on both cells. The IC