Significance of IL-1Ra and IL-6 gene variants in Turkish patients with Crimean-Congo hemorrhagic fever

Umut Safiye Say Coskun; Ayse Feyda Nursal; Ferdi Gunes; Aydin Rustemoglu; Nevin Karakus; Serbulent Yigit; Abdullah Yayli; Huseyin Sener Barut

Return

Significance of IL-1Ra and IL-6 gene variants in Turkish patients with Crimean-Congo hemorrhagic fever

Author: Umut Safiye Say COSKUN ¹ ; Ayse Feyda NURSAL ² ; Ferdi GUNES ³ ; Aydin RUSTEMOGLU ⁴ ; Nevin KARAKUS ⁴ ; Serbulent YIGIT ⁴ ; Abdullah YAYLI ⁵ ; Huseyin Sener BARUT ⁶
Author Information

1. Tokat Gaziosmanpasa University, Medicine Faculty, Department of Medical Microbiology
2. Hitit University, Medicine Faculty, Department of Medical Genetics
3. Obstetrics and Pediatrics Hospital, Clinic of Infectious Disease
4. Tokat Gaziosmanpasa University, Medicine Faculty, Department of Medical Biology
5. Tokat Gaziosmanpasa University, Medicine Faculty, Microbiology Laboratory
6. Tokat Gaziosmanpasa University, Medicine Faculty, Department of Infectious Disease
Publication Type:Journal Article
Keywords: -572GC; -597GA; Crimean-Congo hemorrhagic fever; IL-1Ra; IL-6; Variable number of tandem repeat
From:Asian Pacific Journal of Tropical Biomedicine 2019;9(2):85-90
CountryChina
Language:Chinese
Abstract: Objective: To investigate the association between IL-1Ra variable number of tandem repeat (rs2234663), IL-6 -597GA (rs1800797), IL-6 -572GC (rs1800796) and the risk of Crimean-Congo hemorrhagic fever (CCHF) in the Turkish patients. Methods: This study included 50 patients infected with CCHF and 50 healthy controls. These variants were genotyped using polymerase chain reaction and/or restriction fragment length polymorphism method. Results: The distribution of the IL-6 -572GC genotypes and alleles varied significantly between the patients and the controls. The subjects carrying IL-6 -572GC GG genotype and G allele had increased risk of developing CCHF compared to the control group (P=0.006, P=0.014, respectively). IL-6 -572GC GC genotype was higher in the controls than the patients (P=0.006). For the triple genotype combinations, the 1/2-GC-GG genotype combination was detected more frequently in the control group than CCHF patients (P=0.016). IL-6 (-572/-597) GG-GG genotype was significantly higher in the patient group (P=0.015), while the GC-GG genotype was significantly lower in the patient group (P=0.005). Additionally, the G-G haplotype was significantly higher in the patient group (P=0.042), whereas C-G was found to be significantly lower in the patients than the control group (P=0.037). Conclusions: The results of this study suggest the IL-6 -572GC variant might be genetic markers of sensitivity to CCHF in the Turkish population and may facilitate greater protection against the disease.