Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice

Urarat Nanna; Jarinyaporn Naowaboot; Linda Chularojmontri; Pholawat Tingpej; Suvara Wattanapitayakul

Return

Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice

Author: Urarat NANNA ¹ ; Jarinyaporn NAOWABOOT ¹ ; Linda CHULAROJMONTRI ¹ ; Pholawat TINGPEJ ² ; Suvara WATTANAPITAYAKUL ³
Author Information

1. Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University (Rangsit Campus)
2. Division of Microbiology and Immunology, Department of Preclinical Science, Faculty of Medicine, Thammasat University
3. Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University
Publication Type:Journal Article
Keywords: Brassica oleracea; Insulin resistance; Lipogenesis; Obesity
From:Asian Pacific Journal of Tropical Biomedicine 2019;9(2):80-84
CountryChina
Language:Chinese
Abstract: Objective: To examine the effect of Brassica oleracea extract (BO) on impaired glucose and lipid homeostasis in high-fat diet (HFD)-induced obese mice. Methods: Obesity of ICR mice was induced by feeding a HFD (45 kcal% lard fat) for 16 weeks. During the last 8 weeks of study period, obese mice were additionally administered with BO (100 and 200 mg/kg/day). The metabolic parameters were determined. The gene expressions of hepatic lipogenesis were also studied. Results: After 8 weeks of treatment, BO (100 and 200 mg/kg) significantly reduced hyperglycemia and improved insulin sensitivity (P < 0.05). The serum lipid (total cholesterol, triglyceride, and non-esterified fatty acid) and hepatic triglyceride and non-esterified fatty acid were decreased (P < 0.05). The levels of insulin and leptin in serum were also decreased (P < 0.05). Moreover, the expressions of hepatic lipogenic genes including sterol regulatory element-binding protein 1c, fatty acid synthase, and acetyl-CoA carboxylase were decreased by BO treatment (P < 0.05). Conclusions: These results suggest that BO is a new therapeutic agent for improving the homeostasis of glucose and lipid in HFD-induced obese mice probably by suppression of lipogenic genes in liver tissue.