Trigonella foenum-graecum seed extract modulates expression of lipid metabolism-related genes in HepG2 cells

Maryam Mohammad-sadeghipour; Mehdi Mahmoodi; Mohammad Fahmidehkar; Mohammad Mirzaei; Mojgan Karimabad; Mohammad Hajizadeh; Maryam Mohammad-sadeghipour; Mehdi Mahmoodi; Mohammad Mirzaei; Mojgan Karimabad; Mohammad Hajizadeh; Mehdi Mahmoodi; Soudeh Falahati-pour; Alireza Khoshdel; Mohammad Fahmidehkar

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Trigonella foenum-graecum seed extract modulates expression of lipid metabolism-related genes in HepG2 cells

Author: Maryam MOHAMMAD-SADEGHIPOUR ^{1
,

2} ; Mehdi MAHMOODI ^{1
,

2} ; Mohammad FAHMIDEHKAR ^{1
,

2} ; Mohammad MIRZAEI ^{1
,

2} ; Mojgan KARIMABAD ^{1
,

2} ; Mohammad HAJIZADEH ^{1
,

2} ; Maryam MOHAMMAD-SADEGHIPOUR ³ ; Mehdi MAHMOODI ³ ; Mohammad MIRZAEI ³ ; Mojgan KARIMABAD ³ ; Mohammad HAJIZADEH ³ ; Mehdi MAHMOODI ⁴ ; Soudeh FALAHATI-POUR ⁵ ; Alireza KHOSHDEL ⁶ ; Mohammad FAHMIDEHKAR ⁷
Author Information

1. Department of Clinical Biochemistry, Faculty of Medicine
2. Molecular Medicine Research Center, Inistitute of Basic Medical Sciences Research, Rafsanjan University of Medical Sciences
3. Molecular Medicine Research Center, Inistitute of Basic Medical Sciences Research, Rafsanjan University of Medical Sciences
4. Department of Clinical Biochemistry, Afzalipoor Faculty of Medicine, Kerman University of Medical Sciences
5. Pistachio Safety Research Center, Rafsanjan University of Medical Sciences
6. Department of Clinical Biochemistry, Faculty of Medicine, Pistachio Safety Research Center, Rafsanjan University of Medical Sciences
7. Department of Laboratory Sciences, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences
Publication Type:Journal Article
Keywords: 4-Hydroxy-L-isoleucine; Diosgenin; Dyslipidemia; Fenugreek seed extract; Obesity
From:Asian Pacific Journal of Tropical Biomedicine 2019;9(6):240-248
CountryChina
Language:Chinese
Abstract: Objective: To investigate anti-dyslipidemic effects of hydroalcoholic fenugreek seed extracts, diosgenin, and 4-OH-Ile on HepG2 cell line. Methods: HepG2 cells were treated with hydroalcoholic fenugreek seed extracts, diosgenin, 4-OH-Ile, and orlistat. IC