Galangin ameliorates changes of membrane-bound enzymes in rats with streptozotocin-induced hyperglycemia

Amal ALOUD; Chinnadurai VEERAMANI; Chandramohan GOVINDASAMY; Mohammed ALSAIF; Khalid AL-NUMAIR

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Galangin ameliorates changes of membrane-bound enzymes in rats with streptozotocin-induced hyperglycemia

Author: Amal ALOUD ¹ ; Chinnadurai VEERAMANI ² ; Chandramohan GOVINDASAMY ² ; Mohammed ALSAIF ² ; Khalid AL-NUMAIR ²
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1. Department of Food Sciences and Nutrition, College of Food and Agriculture Sciences, King Saud University
2. Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University
Publication Type:Journal Article
Keywords: Calcium-ATPase; Galangin; Hyperglycemia; Magnesium-ATPase; Sodium-potassium-ATPase; Streptozotocin
From:Asian Pacific Journal of Tropical Biomedicine 2019;9(7):284-290
CountryChina
Language:Chinese
Abstract: Objective: To assess the protective effect of galangin on membrane bound enzymes in rats with streptozotocin-induced diabetes. Methods: A single low dose of streptozotocin was injected to adult male albino rats to induce hyperglycemia. Galangin (8 mg/kg) or glibenclamide 600 μg/kg as a standard drug was given orally once daily for 45 days by gavage. Membrane-bound adenosine triphosphatases were determined including total ATPase, sodium-potassium-ATPase, calcium-ATPase and magnesium-ATPase in erythrocytes and tissues (kidney, liver, and heart). Results: The levels of total ATPases, sodium-potassium-ATPase, calcium-ATPase and magnesium-ATPase in erythrocytes and tissues were significantly altered in diabetic rats as compared to that in normal rats. After 45 days of treatment with galangin or glibenclamide, the levels of these enzymes were similar to that of normal control rats. Conclusions: Oral administration of galangin or glibenclamide can improve activities of these membrane-bound ATPases towards normal levels. Mechanism of galangin needs to be further explored in future.