Standardized extract of Centella asiatica ECa 233 inhibits lipopolysaccharide-induced cytokine release in skin keratinocytes by suppressing ERK1/2 pathways

Author: Furoida MOOLSAP ¹ ; Wanida SUKKETSIRI ¹ ; Supita TANASAWET ² ; Mayuree TANTISIRA ³ ; Pilaiwanwadee HUTAMEKALIN ⁴ ; Varomyalin TIPMANEE ⁵
Author Information

1. Department of Pharmacology, Faculty of Science, Prince of Songkla University
2. Department of Anatomy, Faculty of Science, Prince of Songkla University
3. Faculty of Pharmaceutical Science, Burapha University, Chon Buri Campus
4. Department of Physiology, Faculty of Science, Prince of Songkla University
5. Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University
Publication Type:Journal Article
Keywords: Centella asiatica; Cyclooxygenase-2; HaCaT; Interleukin-1β; Tumor necrosis factor-α
From:Asian Pacific Journal of Tropical Biomedicine 2020;10(6):273-280
CountryChina
Language:Chinese
Abstract: Objective: To evaluate the effect of standardized extract of Centella asiatica ECa 233 on inflammatory mediator production through cyclooxygenase-2 (COX-2), extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor-κB (NF-κB) pathway in keratinocyte HaCaT cells. Methods: HaCaT cells were treated with 0.1, 1, 10 and 100 μg/mL ECa 233 in the presence of lipopolysaccharide (LPS). Proinflammatory cytokines and prostaglandin E