Standardized extract of Centella asiatica ECa 233 inhibits lipopolysaccharide-induced cytokine release in skin keratinocytes by suppressing ERK1/2 pathways
- Author:
Furoida MOOLSAP
1
;
Wanida SUKKETSIRI
1
;
Supita TANASAWET
2
;
Mayuree TANTISIRA
3
;
Pilaiwanwadee HUTAMEKALIN
4
;
Varomyalin TIPMANEE
5
Author Information
- Publication Type:Journal Article
- Keywords: Centella asiatica; Cyclooxygenase-2; HaCaT; Interleukin-1β; Tumor necrosis factor-α
- From:Asian Pacific Journal of Tropical Biomedicine 2020;10(6):273-280
- CountryChina
- Language:Chinese
- Abstract: Objective: To evaluate the effect of standardized extract of Centella asiatica ECa 233 on inflammatory mediator production through cyclooxygenase-2 (COX-2), extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor-κB (NF-κB) pathway in keratinocyte HaCaT cells. Methods: HaCaT cells were treated with 0.1, 1, 10 and 100 μg/mL ECa 233 in the presence of lipopolysaccharide (LPS). Proinflammatory cytokines and prostaglandin E