Allolobophora caliginosa coelomic fluid ameliorates gentamicin-induced hepatorenal toxicity in rats

Saad Dajem; Kareem Morsy; Sara Ali; Omar Abdelrady; Nouraldin Salahaldin; Ahmed Soliman; Yasmin Kamal; Ammar Abdelazim; Aya Mohamed; Kareem Morsy; Ayman Mohamed; Sohair Fahmy

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Allolobophora caliginosa coelomic fluid ameliorates gentamicin-induced hepatorenal toxicity in rats

Author: Saad DAJEM ¹ ; Kareem MORSY ¹ ; Sara ALI ² ; Omar ABDELRADY ² ; Nouraldin SALAHALDIN ² ; Ahmed SOLIMAN ² ; Yasmin KAMAL ² ; Ammar ABDELAZIM ² ; Aya MOHAMED ² ; Kareem MORSY ² ; Ayman MOHAMED ² ; Sohair FAHMY ²
Author Information

1. Department of Biology, College of Science, King Khalid University
2. Department of Zoology, Faculty of Science, Cairo University
Publication Type:Journal Article
Keywords: Allolobophora caliginosa; Coelomic fluid; Earthworm; Gentamicin; Hepatorenal toxicity
From:Asian Pacific Journal of Tropical Biomedicine 2020;10(9):411-416
CountryChina
Language:Chinese
Abstract: Objective: To explore the efficacy of earthworm's coelomic fluid against gentamicin-induced hepatic and renal toxicity in rats. Methods: The animals were divided randomly into three groups (n = 6 per group): control, gentamicin, and Allolobophora caliginosa coelomic fluid-treated groups. Toxicity was established after injection of gentamicin daily for 8 days at a dose of 100 mg/kg. Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total proteins, albumin, creatinine, urea, uric acid, malondialdehyde, glutathione, catalase and histopathology of tissues were investigated in the study. Results: Allolobophora caliginosa coelomic fluid significantly decreased urea, creatinine, uric acid, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and malondialdehyde levels while significantly increasing levels of total proteins, albumin, glutathione and catalase. The histopathological investigation showed partial restoration of renal and hepatic architecture. Conclusions: This study shows the potency of Allolobophora caliginosa coelomic fluid in improving the biochemical and histopathological changes induced by gentamicin in the liver and kidney of the rats.