Chemical characterization, docking studies, anti-arthritic activity and acute oral toxicity of Convolvulus arvensis L. leaves

Author: Uzma SALEEM ¹ ; Shingraf ZAIB ¹ ; Sana KHALID ¹ ; Fareeha ANWAR ² ; Muhammad AKHTAR ² ; Bashir AHMAD ²
Author Information

1. Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University
2. Riphah Institute of Pharmaceutical Sciences, Riphah International University
Publication Type:Journal Article
Keywords: Arthritis; Convolvulus arvensis; Molecular docking; Phytoconstituents
From:Asian Pacific Journal of Tropical Biomedicine 2020;10(10):442-451
CountryChina
Language:Chinese
Abstract: Objective: To evaluate acute oral toxicity and anti-arthritic activity of the methanolic extract of Convolvulus arvensis L. leaves. Methods: Safety was assessed by acute oral toxicity (OECD 425) study. Anti-arthritic activity was explored by in vitro (inhibition of protein denaturation) and in vivo (Complete Freund's adjuvant-induced arthritis and carrageenan-induced inflammation) methods. Antioxidant potential was determined by assessing ferric reducing power, DPPH inhibition, and H