Protective effects of rice bran hydrolysates on heart rate variability, cardiac oxidative stress, and cardiac remodeling in high fat and high fructose diet-fed rats

Ketmanee SENAPHAN; Pisit SUWANNACHOT; Geerasak THIRATANABOON; Ketmanee SENAPHAN; Upa KUKONGVIRIYAPAN; Weerapon SANGARTIT; Ketmanee SENAPHAN; Upa KUKONGVIRIYAPAN; Weerapon SANGARTIT; Upa KUKONGVIRIYAPAN; Weerapon SANGARTIT; Supawan THAWORNCHINSOMBUT; Akkasit JONGJAREONRAK

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Protective effects of rice bran hydrolysates on heart rate variability, cardiac oxidative stress, and cardiac remodeling in high fat and high fructose diet-fed rats

Author: Ketmanee SENAPHAN ¹ ; Pisit SUWANNACHOT ¹ ; Geerasak THIRATANABOON ¹ ; Ketmanee SENAPHAN ² ; Upa KUKONGVIRIYAPAN ² ; Weerapon SANGARTIT ² ; Ketmanee SENAPHAN ³ ; Upa KUKONGVIRIYAPAN ³ ; Weerapon SANGARTIT ³ ; Upa KUKONGVIRIYAPAN ⁴ ; Weerapon SANGARTIT ⁴ ; Supawan THAWORNCHINSOMBUT ⁵ ; Akkasit JONGJAREONRAK ⁵
Author Information

1. Division of Physiology, Faculty of Veterinary Medicine, Khon Kaen University
2. Cardiovascular Research Group, Khon Kaen University
3. Department of Physiology, Faculty of Medicine, Khon Kaen University
4. Department of Food Technology, Faculty of Technology, Khon Kaen University
5. Faculty of Agro-Industry, Chiang Mai University
Publication Type:Journal Article
Keywords: Cardiac remodeling; Heart rate variability; Metabolic syndrome; Oxidative stress; Rice bran hydrolysates
From:Asian Pacific Journal of Tropical Biomedicine 2021;11(5):183-193
CountryChina
Language:Chinese
Abstract: Objective: To examine the ameliorative effect of rice bran hydrolysates (RBH) on metabolic disorders, cardiac oxidative stress, heart rate variability (HRV), and cardiac structural changes in high fat and high fructose (HFHF)-fed rats. Methods: Male Sprague-Dawley rats were daily fed either standard chow diet with tap water or an HFHF diet with 10% fructose in drinking water over 16 weeks. RBH (500 and 1 000 mg/kg/day) was orally administered to the HFHF-diet-fed rats during the last 6 weeks of the study period. At the end of the treatment, metabolic parameters, oxidative stress, HRV, and cardiac structural changes were examined. Results: RBH administration significantly ameliorated metabolic disorders by improving lipid profiles, insulin sensitivity, and hemodynamic parameters. Moreover, RBH restored HRV, as evidenced by decreasing the ratio of low-frequency to high-frequency power of HRV, a marker of autonomic imbalance. Cardiac oxidative stress was also mitigated after RBH supplementation by decreasing cardiac malondialdehyde and protein carbonyl, upregulating eNOS expression, and increasing catalase activity in the heart. Furthermore, RBH mitigated cardiac structural changes by reducing cardiac hypertrophy and myocardial fibrosis in HFHF-diet-fed rats. Conclusions: The present findings suggest that consumption of RBH may exert cardioprotective effects against autonomic imbalances, cardiac oxidative stress, and structural changes in metabolic syndrome.