Potential of polyphenols in curbing quorum sensing and biofilm formation in Gram-negative pathogens

Arnica Lal; Sonam Bhatia; Shaminder Singh; Francisco Franco

Return

Potential of polyphenols in curbing quorum sensing and biofilm formation in Gram-negative pathogens

Author: Arnica LAL ¹ ; Sonam BHATIA ¹ ; Shaminder SINGH ² ; Francisco FRANCO ³
Author Information

1. Department of Pharmaceutical Science, SHALOM Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences
2. Regional Centre for Biotechnology, NCR Biotech Science Cluster
3. Chemistry Department, De la Salle Univers
Publication Type:Journal Article
Keywords: Antibiotic resistance; Biofilm; Polyphenols; Quorum sensing; Recombinant polyphenolic compounds; Sensitizers
From:Asian Pacific Journal of Tropical Biomedicine 2021;11(6):231-243
CountryChina
Language:Chinese
Abstract: Polyphenols are the secondary metabolic products of plants and are considered as active constituents to possess therapeutic effects. To date, a vast number of scientific literature addressed the potential of polyphenols as bio-efficient compounds owing to their structural diversity. Due to the presence of several hydroxyl groups, they are metabolized quickly due to conjugation reaction and thus, readily produce toxic metabolites as a defense material against many pathogens, reflecting their safety strategy. This review focuses on the anti-quorum sensing and biofilm inhibition activity of polyphenols, which display their potential to treat bacterial infections by combating the virulence caused by pathogenic agents. Thus, for mitigating quorum sensing-controlled pathogenesis, the use of polyphenol-based phytochemicals holds immense potential to cure infections. The application of polyphenol as sensitizing agent/ adjuvant therapeutics which act in synergism with antibiotics is highly remarkable.