Anti-viral and anti-inflammatory effects of kaempferol and quercetin and COVID-2019: A scoping review
- Author:
Mohammad Reza KHAZDAIR
1
;
Akbar ANAEIGOUDARI
2
;
Gabriel A. AGBOR
3
Author Information
- Publication Type:Journal Article
- Keywords: Anti-inflammatory; Antiviral effects; Flavonoids; Immunomodulation; Kaempferol; Quercetin; SARS-CoV-2
- From:Asian Pacific Journal of Tropical Biomedicine 2021;11(8):327-334
- CountryChina
- Language:Chinese
- Abstract: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a novel coronavirus identified at the end of 2019. It is recognized as the causative agent of coronavirus disease 2019 (COVID-19). Flavonoids have been shown to exhibit therapeutical effect on complications related to COVID-19. The present study reviews possible therapeutic benefits of flavonoids on SARS-CoV-2. The Web of Science, PubMed, Scopus, and Google Scholar were searched using keywords: 'COVID-19', 'SARS-CoV-2', 'Kaempferol' and 'Quercetin' in the Title/Abstract. Relevant published articles in the English language until August 2020 were considered. Kaempferol and quercetin showed antiviral properties such as inhibition of protein kinase B and phosphorylation of protein kinase and blocking effects on a selective channel (3a channel) expressed in SARS-CoV infected cells. They also reduced the level of reactive oxygen species, expression of inducible nitric oxide synthase, pro-inflammatory mediators including TNF-α, IL-1α, IL-1β, IL-6, IL-10, and IL-12 p70, and chemokines. Kaempferol and quercetin might exert beneficial effects in the control or treatment of COVID-19 because of their antiviral, antioxidant, anti-inflammatory, and immunomodulatory effects.
