Gum resin extract of Boswellia serrata attenuates lipopolysaccharide-induced inflammation and oxidative damage in hepatic and renal tissues of rats

Narges Marefati; Poorya Etemadizadeh; Farimah Beheshti; Farimah Beheshti; Mahmoud Hosseini; Akbar Anaeigoudari

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Gum resin extract of Boswellia serrata attenuates lipopolysaccharide-induced inflammation and oxidative damage in hepatic and renal tissues of rats

Author: Narges MAREFATI ¹ ; Poorya ETEMADIZADEH ¹ ; Farimah BEHESHTI ² ; Farimah BEHESHTI ³ ; Mahmoud HOSSEINI ⁴ ; Akbar ANAEIGOUDARI ⁵
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1. Applied Biomedical Research Center, Mashhad University Of Medical Sciences
2. Neuroscience Research Center, Department Of Physiology, School Of Paramedical Sciences, Torbat Heydariyeh University Of Medical Sciences
3. Department Of Physiology, School Of Paramedical Sciences, Torbat Heydariyeh University Of Medical Sciences
4. Division Of Neurocognitive Sciences, Psychiatry And Behavioral Sciences Research Center, Mashhad University Of Medical Sciences
5. Department Of Physiology, School Of Medicine, Jiroft University Of Medical Sciences
Publication Type:Journal Article
Keywords: Boswellia serrata; Hepatic function; Inflammation; Lipopolysaccharide; Oxidative stress; Renal function
From:Asian Pacific Journal of Tropical Biomedicine 2022;12(1):20-25
CountryChina
Language:English
Abstract: Objective: To explore the effect of ethyl acetate gum resin extract of Boswellia serrata on lipopolysaccharide (LPS) induced inflammation and oxidative damage in hepatic and renal tissues of rats. Methods: The rats were divided into four groups: control, LPS, LPS+Boswellia serrata extracts (100 mg/kg and 200 mg/kg). LPS (1 mg/kg) and the extract (100 and 200 mg/kg, 30 min before LPS) were administered intraperitoneally for 3 weeks. The levels of liver enzymes, albumin, total protein, creatinine, blood urea nitrogen (BUN), interleukin (IL)-6, malondialdehyde (MDA), and total thiol groups and superoxide dismutase (SOD) and catalase (CAT) activities were measured. Results: The levels of liver enzymes, creatinine, and BUN, IL-6, MDA in the LPS group were markedly increased (P<0.001) while albumin, total protein, and total thiol concentration, as well as SOD and CAT activities, were decreased compared with the control group (P<0.05 or 0.01). Boswellia serrata extracts diminished the levels of liver enzymes, creatinine, BUN, IL-6, and MDA (P<0.01 and P<0.001), and elevated the concentration of total protein and total thiol and SOD and CAT activities (P<0.05 or 0.01). Conclusions: The ethyl acetate gum resin extract of Boswellia serrata reduces LPS-induced inflammatory reactions and oxidative damage, thus ameliorating hepatic and renal function.