Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice

Fardin Khajepour; Mohammad Reza Zangouyee; Arezu Khosravimashizi; Reza Nosratabadi; Ali Afgar; Ali Afgar; Vahideh Abdollahi; Shahriar Dabiri; Shahriar Dabiri; Reza Nosratabadi

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Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice

Author: Fardin KHAJEPOUR ¹ ; Mohammad Reza ZANGOUYEE ¹ ; Arezu KHOSRAVIMASHIZI ¹ ; Reza NOSRATABADI ¹ ; Ali AFGAR ² ; Ali AFGAR ³ ; Vahideh ABDOLLAHI ⁴ ; Shahriar DABIRI ⁵ ; Shahriar DABIRI ⁶ ; Reza NOSRATABADI ⁷
Author Information

1. Department of Medical Immunology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences
2. Research Center for Hydatid Disease in Iran, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences
3. Student Research Committee, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences
4. Department of Animal Biology, Kharazmi University
5. Department of Pathology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences
6. Pathology and Stem Cells Research Center, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences
7. Gastroenterology and Hepathology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences
Publication Type:Journal Article
Keywords: 2,4 dinitrochlorobenzene; Atopic dermatitis; Caraway; Carum carvi L; Oxidative stress; Th1; Th2
From:Asian Pacific Journal of Tropical Biomedicine 2022;12(10):421-429
CountryChina
Language:English
Abstract: Objective: To explore the anti-inflammatory and antioxidant effects of caraway on atopic dermatitis (AD) in mice. Methods: AD was induced in two stages, including sensitization and challenge with the application of 2,4 dinitrochlorobenzene 2% and 0.2%, respectively. Clinical symptoms and histological analysis of the skin were assessed. The effects of caraway on oxidant/ antioxidant parameters as well as Th1- and Th2-related cytokines were also evaluated. Results: Caraway reduced the severity of dermatitis in AD-induced mice, as evidenced by significant inhibition of Th2-related cytokines (IL-4 and IL-13) and increased Th1-related cytokine (IFN-γ). Additionally, treatment with caraway significantly increased superoxide dismutase and catalase activity and decreased the malondialdehyde level in the serum of AD mice. Furthermore, caraway inhibited the differentiation of Th2 cells while favoring Th1 cell differentiation in the spleen via regulating their master transcription factors GATA3 and T-bet. Conclusions: Caraway could improve AD autoimmune responses and could be considered a potential candidate to treat AD disease.