Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses.
10.1016/j.apsb.2022.08.025
- Author:
Shilin CHEN
1
;
Zheng LI
2
;
Sanyin ZHANG
3
;
Yuxin ZHOU
1
;
Xiaohe XIAO
4
;
Pengdi CUI
2
;
Binjie XU
3
;
Qinghe ZHAO
5
;
Shasha KONG
5
;
Yuntao DAI
5
Author Information
1. Institute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
2. State Key Laboratory of Component Traditional Chinese Medicine, College of Pharmaceutical Engineering of Traditional Chinese Medicine, Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
3. Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
4. China Military Institute of Chinese Medicine, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
5. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
- Publication Type:Review
- Keywords:
Biotechnology;
Manufacturing control;
Pharmaceutical analysis;
Quality analysis;
Raw materials
- From:
Acta Pharmaceutica Sinica B
2022;12(11):4075-4097
- CountryChina
- Language:English
-
Abstract:
Pharmaceutical analysis is a discipline based on chemical, physical, biological, and information technologies. At present, biotechnological analysis is a short branch in pharmaceutical analysis; however, bioanalysis is the basis and an important part of medicine. Biotechnological approaches can provide information on biological activity and even clinical efficacy and safety, which are important characteristics of drug quality. Because of their advantages in reflecting the overall biological effects or functions of drugs and providing visual and intuitive results, some biotechnological analysis methods have been gradually applied to pharmaceutical analysis from raw material to manufacturing and final product analysis, including DNA super-barcoding, DNA-based rapid detection, multiplex ligation-dependent probe amplification, hyperspectral imaging combined with artificial intelligence, 3D biologically printed organoids, omics-based artificial intelligence, microfluidic chips, organ-on-a-chip, signal transduction pathway-related reporter gene assays, and the zebrafish thrombosis model. The applications of these emerging biotechniques in pharmaceutical analysis have been discussed in this review.
