Discovery of novel heteroaryl alkynes for highly potent KIT<sup>D816V</sup> cells inhibition to treat gastrointestinal stromal tumors.

Author: Zhicheng XIE ¹ ; Lin LI ¹ ; Yihao GUO ² ; Mi ZHANG ¹ ; Taiwen CHEN ¹ ; Yongpeng LI ² ; Xin LI ¹ ; Xi ZHU ¹ ; Yu ZHANG ¹ ; Liguang LOU ¹ ; Youhong HU ¹
Author Information

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
2. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Publication Type:Journal Article
Keywords: Drug resistance; Gastrointestinal stromal tumors; KITD816Vcells; Mutation
From: Acta Pharmaceutica Sinica B 2022;12(10):4004-4007
CountryChina
Language:English