Rapid screening of SARS-CoV-2 inhibitors <i>via</i> ratiometric fluorescence of RBD-ACE2 complexes in living cells by competitive binding.

Author: Lu MIAO ¹ ; Wei ZHOU ¹ ; Chunyu YAN ¹ ; Yuebin ZHANG ² ; Qinglong QIAO ¹ ; Xuelian ZHOU ¹ ; Yingzhu CHEN ¹ ; Guangying WANG ¹ ; Zhendong GUO ³ ; Jun LIU ³ ; Hailong PIAO ¹ ; Xia PAN ⁴ ; Mengxue YAN ⁴ ; Weijie ZHAO ⁴ ; Guohui LI ² ; Yueqing LI ⁴ ; Zhaochao XU ¹
Author Information

1. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
2. State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
3. Institute of Military Veterinary Science, The Academy of Military Medical Science of PLA, Changchun 130000, China.
4. State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Publication Type:Journal Article
Keywords: Inhibitors screening; Live-cell imaging; RBD–ACE2 interaction; SARS-CoV-2
From: Acta Pharmaceutica Sinica B 2022;12(9):3739-3742
CountryChina
Language:English