A systematic review on the safety of Psoraleae Fructus: potential risks, toxic characteristics, underlying mechanisms and detoxification methods.
10.1016/S1875-5364(22)60234-6
- Author:
Zhuo SHI
1
;
Jing GAO
2
;
Jinchao PAN
2
;
Zuqi ZHANG
2
;
Guangchen ZHANG
2
;
Yuguang WANG
3
;
Yue GAO
4
Author Information
1. Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address: cpu_shizhuo@163.com.
2. Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
3. Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address: wangyg@bmi.ac.cn.
4. Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address: gaoyue@bmi.ac.cn.
- Publication Type:Review
- Keywords:
Detoxification compatibility;
Hepatotoxicity;
Psoralea corylifolia L.;
Psoraleae Fructus;
Toxic characteristics;
Toxic substances
- MeSH:
Drugs, Chinese Herbal/toxicity*;
Fruit/toxicity*;
Liver
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(11):805-813
- CountryChina
- Language:English
-
Abstract:
Psoraleae Fructus (PF) is an important traditional herbal medicine with a long history of clinical application. It is widely used to treat various diseases, such as osteoporosis, leucoderma and diarrhea. As a traditional nontoxic herb, it has aroused worldwide concern about the potential risks due to increasing adverse reaction events. This article reviews the botany, ancient records of medical uses, adverse reactions, toxicological research advance and detoxification methods of PF. According to clinical studies, liver injury is the most predominant in PF-related adverse reactions. The underlying mechanisms include bile acid metabolism and transport disorders, oxidative stress, mitochondrial damage, inhibition of liver cell regeneration and inflammatory reactions. Furthermore, the potential toxins of PF are summarized. Traditional methods of processing and compatibility will provide reference for reducing the toxicity of PF, which requires further research. In sum, this work systematically summarizes the reserach progress on the safety of PF, which will provide comprehensive insights into the toxicity of PF and facilitate its safe use and future development.
