Tetracycline natural products: discovery, biosynthesis and engineering.
10.1016/S1875-5364(22)60224-3
- Author:
Haiyan WANG
1
;
Lijun WANG
1
;
Keqiang FAN
1
;
Guohui PAN
2
,
3
Author Information
1. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
2. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
3. University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: panguohui@im.ac.cn.
- Publication Type:Review
- Keywords:
Biosynthesis;
Engineering;
Polyketide synthases;
Tetracycline
- MeSH:
Humans;
Biological Products/metabolism*;
Anti-Bacterial Agents;
Metabolic Engineering;
Synthetic Biology;
Tetracycline
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(10):773-794
- CountryChina
- Language:English
-
Abstract:
Tetracycline (TC) natural products possess a variety of remarkable bioactivities and diverse structures. They are an important and fertile source for developing novel drugs. As one of the most successful drug families, TC antibiotics have been in clinical use for over seven decades, and continue to make an important contribution to human health nowadays. To date, studies on TC natural products and their biosynthesis have revealed numerous novel biochemical mechanisms and regulatory elements, which facilitates the rational metabolic engineering studies for generating novel bioactive TC analogs and inspires the development of new synthetic biology tools. In this review, we provide a comprehensive overview on the discovery, biosynthesis, and engineering of the existing TC natural products. These analyses will be of great value for the discovery, design and development of novel TC drugs in the future.
