Biosynthesis and regulation of diterpenoids in medicinal plants.
10.1016/S1875-5364(22)60214-0
- Author:
Junze REN
1
;
Yu WU
1
;
Zhanpin ZHU
1
;
Ruibing CHEN
2
;
Lei ZHANG
3
,
4
,
5
Author Information
1. Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
2. Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai 200433, China. Electronic address: rbchenstar@163.com.
3. Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai 200433, China
4. Institute of Interdisciplinary Integrative Medicine Research, School of Medicine, Nantong University, Nantong 226001, China
5. Biomedical Innovation R&D Center, School of Medicine, Shanghai University, Shanghai 20444, China. Electronic address: nmu_dpb@aliyun.com.
- Publication Type:Review
- Keywords:
Biosynthesis;
Diterpenoid;
Medicinal plant;
Pharmaceutical value;
Regulation
- MeSH:
Plants, Medicinal/metabolism*;
Diterpenes/chemistry*;
Metabolic Engineering;
Biosynthetic Pathways;
Biological Products/metabolism*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(10):761-772
- CountryChina
- Language:English
-
Abstract:
Plant diterpenoids are widely distributed and abundant natural products with diverse structures and functions in nature, which have been commonly used in pharmaceutical, agricultural and industrial production. In recent years, plant diterpenoids have attracted increasing attention, including their biosynthetic pathways, transcriptional regulatory networks, and biological functions. Herein, the biosynthetic pathways of diterpenoids are summarized in a modular fashion. Further, the regulatory network between diterpene biosynthesis and environmental factors is reviewed. Insights into diterpene metabolism may drive elucidation of complex active diterpene pathways and serve as a knowledge repository for metabolic engineering and cell factory construction.
