Covalent flavoproteins: types, occurrence, biogenesis and catalytic mechanisms.
10.1016/S1875-5364(22)60194-8
- Author:
Minjun WANG
1
;
Wenyuan ZHANG
1
;
Nan WANG
2
Author Information
1. Ocean College, Zhejiang University, Zhoushan 316021, China.
2. Ocean College, Zhejiang University, Zhoushan 316021, China. Electronic address: n_wang@zju.edu.cn.
- Publication Type:Review
- Keywords:
Biosynthesis;
Covalent linkage;
Flavoprotein;
Natural products
- MeSH:
Flavoproteins/metabolism*;
Flavin-Adenine Dinucleotide/metabolism*;
Flavin Mononucleotide/metabolism*;
Riboflavin;
Biological Products
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(10):749-760
- CountryChina
- Language:English
-
Abstract:
Flavoproteins are proteins that contain a nucleic acid derivative of riboflavin: flavin adenine dinucleotide (FAD) or flavin mononucleotide (FMN). Flavoproteins are involved in a wide array of biological processes, such as photosynthesis, DNA repair and natural product biosynthesis. It should be noted that 5%-10% of flavoproteins have a covalently linked flavin prosthetic group. Such covalent linkages benefit the holoenzyme in several ways including improving the stability and catalytic potency. During the past decade, significant progress has been made in covalent flavoproteins, especially with respect to enzyme-dependent biogenesis and discovery of novel linkage types. The present review gives a condensed overview of investigations published from March 2009 to December 2021, with emphasis on the discovery, biogenesis and their catalytic role in natural product biosynthesis.
