Drimane-type sesquiterpenoids from fungi.
10.1016/S1875-5364(22)60190-0
- Author:
Wenyu DU
1
;
Qian YANG
1
;
Huimin XU
2
;
Liaobin DONG
3
Author Information
1. State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
2. The Public Laboratory Platform, China Pharmaceutical University, Nanjing 211198, China.
3. State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. Electronic address: ldong@cpu.edu.cn.
- Publication Type:Review
- Keywords:
Bioactivity;
Biosynthesis;
Chemical structures;
Drimane-type sesquiterpenoids;
Fungi
- MeSH:
Polycyclic Sesquiterpenes;
Sesquiterpenes/chemistry*;
Fungi;
Terpenes/chemistry*;
Diterpenes
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(10):737-748
- CountryChina
- Language:English
-
Abstract:
Sesquiterpenoids are comprised of three C5 units and derived from farnesyl diphosphate. In these C15 family of terpenoids, drimane-type sesquiterpenoids are unique as their chemical structure of decahydronaphthalene along with the methyl group decorations resemble the A/B rings of labdane derived diterpenoids and the eastern part of many meroterpenoids. In the past decades, based on their chemical structural features and diverse bioactivities, great efforts have been made to perform chemical and biological research on this family of natural products, leading to the characterization of a large of new compounds and a few biosynthetic pathways. In this review, we collected 164 new drimane-type sesquiterpenoids from fungi between January 2004 and October 2021 and classified them into three major subfamilies, so as to highlight their diverse chemical structures, biological activities, and biosynthetic pathways,.
