Targeting the biological activity and biosynthesis of hyperforin: a mini-review.
10.1016/S1875-5364(22)60189-4
- Author:
Shuqin LIU
1
;
Beilei YU
1
;
Jungui DAI
1
;
Ridao CHEN
2
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: chenridao@imm.ac.cn.
- Publication Type:Review
- Keywords:
Bioactivity;
Biosynthesis;
Hyperforin;
PPAPs;
Prenyltransferase
- MeSH:
Phloroglucinol/chemistry*;
Terpenes/chemistry*;
Hypericum/chemistry*;
Molecular Structure
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(10):721-728
- CountryChina
- Language:English
-
Abstract:
Hyperforin is a representative polycyclic polyprenylated acylphloroglucinols (PPAPs) that exerts a variety of pharmacological activities. The complete biosynthesis pathway of hyperforin has not been elucidated due to its complex structure and unclear genetic background of its source plants. This mini-review focuses on the bioactivity and biosynthesis of hyperforin. These analyses can provide useful insights into the biosynthesis investigations of hyperforin and other PPAPs with complex structures.
