Diverse sesquiterpenoids from Litsea lancilimba Merr. with potential neuroprotective effects against H2O2-induced SH-SY5Y cell injury.
10.1016/S1875-5364(22)60199-7
- Author:
Yi-Jie ZHANG
1
,
2
,
3
,
4
;
Ming BAI
1
,
2
,
3
,
4
;
Jia-Yi LI
1
,
2
,
3
,
4
;
Shu-Yan QIN
1
,
2
,
3
,
4
;
Yu-Yang LIU
1
,
2
,
3
,
4
;
Xiao-Xiao HUANG
1
,
2
,
3
,
4
;
Jiang ZHENG
5
,
6
;
Shao-Jiang SONG
1
,
2
,
3
,
7
Author Information
1. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province
2. Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province
3. Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang
4. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
5. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
6. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang 550004, China. Electronic address: zhengneu@yahoo.com.
7. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: songsj99@163.com.
- Publication Type:Journal Article
- Keywords:
Lauraceae;
Litsea lancilimba;
Neuroprotective effect;
Sesquiterpenoids
- MeSH:
Chromatography, Liquid;
Humans;
Hydrogen Peroxide/toxicity*;
Litsea;
Molecular Structure;
Neuroblastoma/drug therapy*;
Neuroprotective Agents/pharmacology*;
Sesquiterpenes/chemistry*;
Tandem Mass Spectrometry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(9):701-711
- CountryChina
- Language:English
-
Abstract:
Five undescribed sesquiterpenoids (1-5), and nine known sesquiterpenoids (6-14) were obtained from the fruits of Litsea lancilimba Merr. by LC-MS/MS molecular networking strategies. Litsemene A (1) possessed a unique 8-member ring through unexpected cyclization of the methyl group on C-10 of guaiane. Their structures were elucidated by spectroscopic techniques including IR, UV, NMR, HR-ESI-MS, and their absolute configurations were assigned by ECD calculations. All isolated sesquiterpenoids were analyzed by bioinformatics and evaluated for their neuroprotective effects against H2O2-induced injury in human neuroblastoma SH-SY5Y cells.
