New antibacterial depsidones from an ant-derived fungus Spiromastix sp. MY-1.
10.1016/S1875-5364(22)60170-5
- Author:
Zhi-Kai GUO
1
,
2
;
Wen-Yong ZHU
1
,
3
;
Li-Xing ZHAO
1
,
4
;
Yan-Chi CHEN
5
;
Sui-Jun LI
5
;
Ping CHENG
5
;
Hui-Ming GE
5
;
Ren-Xiang TAN
5
;
Rui-Hua JIAO
6
Author Information
1. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210093, China
2. Hainan Key Laboratory of Tropical Microbe Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
3. Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming 650118, China.
4. Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China.
5. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210093, China.
6. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210093, China. Electronic address: rhjiao@nju.edu.cn.
- Publication Type:Journal Article
- Keywords:
Antibacterial;
Depsidones;
Fungus;
Phytopathogenic bacteria;
Spiromastix sp.
- MeSH:
Animals;
Anti-Bacterial Agents;
Ants;
Bromides;
Depsides;
Fungi;
Lactones;
Microbial Sensitivity Tests;
Molecular Structure
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(8):627-632
- CountryChina
- Language:English
-
Abstract:
Six new (1-6) and seven known depsidones (7-13) were isolated from the culture of an ant (Monomorium chinensis)-derived fungus Spiromastix sp. MY-1. Their structures were elucidated by extensive spectroscopic analysis including high resolution MS, 1D and 2D NMR data. The new bromide depsidones were obtained through supplementing potassium bromide in the fermentation medium of Spiromastix sp. MY-1. All isolated compounds showed various bioactivities against the tested phytopathogenic bacteria. Particularly, new bromide compound 4, named spiromastixone S, exhibited the strongest activity against Xanthomonas oryzae pv. oryzae with a MIC value of 5.2 μmol·-1.
