Centranthera grandiflore alleviates alcohol-induced oxidative stress and cell apoptosis.
10.1016/S1875-5364(22)60181-X
- Author:
Xin-Mei GAO
1
;
Wen-Han DONG
2
;
Chun-Lei XIA
1
;
Zhuo-Yi MA
1
;
Ying WANG
1
;
Setrerrahmane SARRA
3
;
Han-Mei XU
1
;
Wei-Yan QI
4
Author Information
1. The Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation, Jiangsu Province, State Key Laboratory of Natural Medicines, Ministry of Education, Department of Marine Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
2. Science and Technology Administration Department of Yunnan Agricultural University, Yunnan 650205, China.
3. Nanjing Anji Biotechnology Co., Ltd., Nanjing 210033, China.
4. The Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation, Jiangsu Province, State Key Laboratory of Natural Medicines, Ministry of Education, Department of Marine Pharmacy, China Pharmaceutical University, Nanjing 211198, China. Electronic address: qiwy05@126.com.
- Publication Type:Journal Article
- Keywords:
Alcohol liver diseases;
Apoptosis;
Centranthera grandiflora;
Hepatoprotective effect;
Oxidative stress
- MeSH:
Animals;
Apoptosis;
Chemical and Drug Induced Liver Injury, Chronic;
Ethanol;
Humans;
Liver;
Liver Diseases, Alcoholic;
Mice;
Oxidative Stress
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(8):572-579
- CountryChina
- Language:English
-
Abstract:
Alcohol liver disease (ALD) has become a global threat to human health. It is associated with a wide range of liver diseases including alcohol fatty liver, steatosis, fibrosis and cirrhosis, and finally leads to liver cancer and even death. Centranthera grandiflora is a traditional Chinese medicinal herb commonly used to treat ALD, but no research about its mechanism is available. This study evaluated the hepatoprotective effect and mechanism of C. grandiflora against alcohol-induced liver injury in mice. We found that the ethanol extracts of C. grandiflora (CgW) alleviated the alcohol-induced liver injury, enhanced the levels of antioxidant enzymes, and reduced the amount of lipid peroxides. CgW also affected cell apoptosis by inhibiting the activity of Bax, cleaved-caspase 3 and cleaved-caspase 9, and increasing the activity of Bcl-2. In conclusion, the results showed that CgW can effectively improve ALD through alleviating oxidative stress and inhibiting cell apoptosis for the first time. This study suggested that C. grandiflora is a promising herbal medicine for ALD treatment.
