Methodology of network pharmacology for research on Chinese herbal medicine against COVID-19: A review.
10.1016/j.joim.2022.09.004
- Author:
Yi-Xuan WANG
1
,
2
;
Zhen YANG
3
;
Wen-Xiao WANG
3
;
Yu-Xi HUANG
3
;
Qiao ZHANG
3
;
Jia-Jia LI
3
;
Yu-Ping TANG
3
;
Shi-Jun YUE
4
Author Information
1. Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, Shaanxi Province, China
2. Department of Scientific Research, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi Province, China.
3. Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, Shaanxi Province, China.
4. Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, Shaanxi Province, China. Electronic address: shijun_yue@163.com.
- Publication Type:Review
- Keywords:
COVID-19;
Chinese traditional medicine;
Compound identification;
Herbal medicine;
Network pharmacology
- MeSH:
Humans;
Drugs, Chinese Herbal/therapeutic use*;
Network Pharmacology;
Medicine, Chinese Traditional/methods*;
Treatment Outcome;
COVID-19 Drug Treatment
- From:
Journal of Integrative Medicine
2022;20(6):477-487
- CountryChina
- Language:English
-
Abstract:
Traditional Chinese medicine, as a complementary and alternative medicine, has been practiced for thousands of years in China and possesses remarkable clinical efficacy. Thus, systematic analysis and examination of the mechanistic links between Chinese herbal medicine (CHM) and the complex human body can benefit contemporary understandings by carrying out qualitative and quantitative analysis. With increasing attention, the approach of network pharmacology has begun to unveil the mystery of CHM by constructing the heterogeneous network relationship of "herb-compound-target-pathway," which corresponds to the holistic mechanisms of CHM. By integrating computational techniques into network pharmacology, the efficiency and accuracy of active compound screening and target fishing have been improved at an unprecedented pace. This review dissects the core innovations to the network pharmacology approach that were developed in the years since 2015 and highlights how this tool has been applied to understanding the coronavirus disease 2019 and refining the clinical use of CHM to combat it.
