Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332.
10.1007/s13238-021-00883-2
- Author:
Yao ZHAO
1
;
Chao FANG
2
;
Qi ZHANG
1
;
Ruxue ZHANG
3
;
Xiangbo ZHAO
2
;
Yinkai DUAN
1
;
Haofeng WANG
1
;
Yan ZHU
1
;
Lu FENG
1
;
Jinyi ZHAO
1
;
Maolin SHAO
1
;
Xiuna YANG
1
;
Leike ZHANG
3
;
Chao PENG
4
;
Kailin YANG
5
;
Dawei MA
6
;
Zihe RAO
7
;
Haitao YANG
8
Author Information
1. Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
2. State Key Laboratory of Bioorganic & Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200032, China.
3. State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
4. National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210, China.
5. Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, 44195, USA.
6. State Key Laboratory of Bioorganic & Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200032, China. madw@sioc.ac.cn.
7. Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. raozh@mail.tsinghua.edu.cn.
8. Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. yanght@shanghaitech.edu.cn.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Antiviral Agents/pharmacology*;
COVID-19;
Coronavirus 3C Proteases;
Humans;
Lactams;
Leucine;
Molecular Docking Simulation;
Molecular Dynamics Simulation;
Nitriles;
Proline;
Protease Inhibitors/pharmacology*;
SARS-CoV-2
- From:
Protein & Cell
2022;13(9):689-693
- CountryChina
- Language:English
