Emerging roles of spliceosome in cancer and immunity.
10.1007/s13238-021-00856-5
- Author:
Hui YANG
1
;
Bruce BEUTLER
2
;
Duanwu ZHANG
3
Author Information
1. Department of Neurosurgery, Huashan Hospital, Shanghai Key laboratory of Brain Function Restoration and Neural Regeneration, MOE Frontiers Center for Brain Science, Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
2. Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. bruce.beutler@utsouthwestern.edu.
3. Children's Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. duanwu@fudan.edu.cn.
- Publication Type:Research Support, Non-U.S. Gov't
- Keywords:
cancer;
immune dysregulation;
innate immunity;
spliceosome;
splicing
- MeSH:
Humans;
Neoplasms/metabolism*;
RNA Precursors/metabolism*;
RNA Splicing;
RNA Splicing Factors/metabolism*;
Spliceosomes/metabolism*
- From:
Protein & Cell
2022;13(8):559-579
- CountryChina
- Language:English
-
Abstract:
Precursor messenger RNA (pre-mRNA) splicing is catalyzed by an intricate ribonucleoprotein complex called the spliceosome. Although the spliceosome is considered to be general cell "housekeeping" machinery, mutations in core components of the spliceosome frequently correlate with cell- or tissue-specific phenotypes and diseases. In this review, we expound the links between spliceosome mutations, aberrant splicing, and human cancers. Remarkably, spliceosome-targeted therapies (STTs) have become efficient anti-cancer strategies for cancer patients with splicing defects. We also highlight the links between spliceosome and immune signaling. Recent studies have shown that some spliceosome gene mutations can result in immune dysregulation and notable phenotypes due to mis-splicing of immune-related genes. Furthermore, several core spliceosome components harbor splicing-independent immune functions within the cell, expanding the functional repertoire of these diverse proteins.
