Expert consensus on regenerative endodontic procedures.

Xi Wei; Maobin Yang; Lin Yue; Dingming Huang; Xuedong Zhou; Xiaoyan Wang; Qi Zhang; Lihong Qiu; Zhengwei Huang; Hanguo Wang; Liuyan Meng; Hong LI; Wenxia Chen; Xiaoying Zou; Junqi Ling

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Expert consensus on regenerative endodontic procedures.

Author: Xi WEI ¹ ; Maobin YANG ² ; Lin YUE ³ ; Dingming HUANG ⁴ ; Xuedong ZHOU ⁴ ; Xiaoyan WANG ³ ; Qi ZHANG ⁵ ; Lihong QIU ⁶ ; Zhengwei HUANG ^{7
,

8
,

9
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10
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11} ; Hanguo WANG ¹² ; Liuyan MENG ¹³ ; Hong LI ¹⁴ ; Wenxia CHEN ¹⁵ ; Xiaoying ZOU ³ ; Junqi LING ¹⁶
Author Information

1. Department of Operative Dentistry and Endodontics, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, China.
2. Department of Endodontology, Maurice H Kornberg School of Dentistry, Temple University, Philadelphia, Pennsylvania, USA.
3. Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, China.
4. State Key Laboratory of Oral Diseases & Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, National Center of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu, China.
5. Department of Endodontics, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.
6. Department of Endodontics, School of Stomatology, China Medical University, Shenyang, Liaoning, China.
7. Department of Endodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
8. College of Stomatology, Shanghai Jiao Tong University
9. National Clinical Research Center for Oral Diseases
10. National Center for Stomatology
11. Shanghai Key Laboratory of Stomatology, Shanghai, China.
12. Department of Operative Dentistry & Endodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
13. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
14. Department of Endodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, China.
15. College of Stomatology, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China.
16. Department of Operative Dentistry and Endodontics, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, China. lingjq@mail.sysu.edu.cn.
Publication Type:Review
MeSH: Humans; Consensus; Regenerative Endodontics; Dental Pulp Necrosis/therapy*; Dentists; Professional Role; Dental Care
From: International Journal of Oral Science 2022;14(1):55-55
CountryChina
Language:English
Abstract: Regenerative endodontic procedures (REPs) is a biologic-based treatment modality for immature permanent teeth diagnosed with pulp necrosis. The ultimate objective of REPs is to regenerate the pulp-dentin complex, extend the tooth longevity and restore the normal function. Scientific evidence has demonstrated the efficacy of REPs in promotion of root development through case reports, case series, cohort studies, and randomized controlled studies. However, variations in clinical protocols for REPs exist due to the empirical nature of the original protocols and rapid advancements in the research field of regenerative endodontics. The heterogeneity in protocols may cause confusion among dental practitioners, thus guidelines and considerations of REPs should be explicated. This expert consensus mainly discusses the biological foundation, the available clinical protocols and current status of REPs in treating immature teeth with pulp necrosis, as well as the main complications of this treatment, aiming at refining the clinical management of REPs in accordance with the progress of basic researches and clinical studies, suggesting REPs may become a more consistently evidence-based option in dental treatment.