Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation.
10.1038/s41368-022-00199-9
- Author:
Yunfeng LIN
1
,
2
,
3
;
Qian LI
4
;
Lihua WANG
5
;
Quanyi GUO
6
,
7
;
Shuyun LIU
6
,
7
;
Shihui ZHU
8
;
Yu SUN
8
;
Yujiang FAN
9
;
Yong SUN
10
;
Haihang LI
11
;
Xudong TIAN
11
;
Delun LUO
12
;
Sirong SHI
1
,
2
,
13
Author Information
1. State Key Laboratory of Oral Diseases &
2. National Clinical Research Center for Oral Diseases &
3. Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China. yunfenglin@scu.edu.cn.
4. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.
5. The Interdisciplinary Research Center, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Zhangjiang Laboratory, Shanghai, China.
6. Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma &
7. War Injuries PLA, Beijing, China.
8. Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
9. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.
10. College of Biomedical Engineering, Sichuan University, Chengdu, China.
11. Jiangsu Trautec Medical Technology Company Limited, Changzhou, China.
12. Chengdu Jingrunze Gene Technology Company Limited, Chengdu, China.
13. Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China. sirongshi@scu.edu.cn.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Nucleic Acids/chemistry*;
Regenerative Medicine;
Consensus;
Reproducibility of Results;
DNA/chemistry*
- From:
International Journal of Oral Science
2022;14(1):51-51
- CountryChina
- Language:English
-
Abstract:
With the emergence of DNA nanotechnology in the 1980s, self-assembled DNA nanostructures have attracted considerable attention worldwide due to their inherent biocompatibility, unsurpassed programmability, and versatile functions. Especially promising nanostructures are tetrahedral framework nucleic acids (tFNAs), first proposed by Turberfield with the use of a one-step annealing approach. Benefiting from their various merits, such as simple synthesis, high reproducibility, structural stability, cellular internalization, tissue permeability, and editable functionality, tFNAs have been widely applied in the biomedical field as three-dimensional DNA nanomaterials. Surprisingly, tFNAs exhibit positive effects on cellular biological behaviors and tissue regeneration, which may be used to treat inflammatory and degenerative diseases. According to their intended application and carrying capacity, tFNAs could carry functional nucleic acids or therapeutic molecules through extended sequences, sticky-end hybridization, intercalation, and encapsulation based on the Watson and Crick principle. Additionally, dynamic tFNAs also have potential applications in controlled and targeted therapies. This review summarized the latest progress in pure/modified/dynamic tFNAs and demonstrated their regenerative medicine applications. These applications include promoting the regeneration of the bone, cartilage, nerve, skin, vasculature, or muscle and treating diseases such as bone defects, neurological disorders, joint-related inflammatory diseases, periodontitis, and immune diseases.
