A 3D-printed molybdenum-containing scaffold exerts dual pro-osteogenic and anti-osteoclastogenic effects to facilitate alveolar bone repair.
10.1038/s41368-022-00195-z
- Author:
Beimin TIAN
1
;
Xuan LI
1
;
Jiujiu ZHANG
1
;
Meng ZHANG
2
;
Dian GAN
1
;
Daokun DENG
1
;
Lijuan SUN
1
;
Xiaotao HE
1
;
Chengtie WU
3
;
Faming CHEN
4
Author Information
1. Department of Periodontology, State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, School of Stomatology, Fourth Military Medical University, Xi'an, China.
2. State Key Laboratory of High-Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
3. State Key Laboratory of High-Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China. chengtiewu@mail.sic.ac.cn.
4. Department of Periodontology, State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, School of Stomatology, Fourth Military Medical University, Xi'an, China. cfmsunhh@fmmu.edu.cn.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Bone Regeneration;
Cell Differentiation;
Ions/pharmacology*;
Molybdenum/pharmacology*;
Osteoclasts;
Osteogenesis;
Printing, Three-Dimensional;
Tissue Scaffolds/chemistry*
- From:
International Journal of Oral Science
2022;14(1):45-45
- CountryChina
- Language:English
-
Abstract:
The positive regulation of bone-forming osteoblast activity and the negative feedback regulation of osteoclastic activity are equally important in strategies to achieve successful alveolar bone regeneration. Here, a molybdenum (Mo)-containing bioactive glass ceramic scaffold with solid-strut-packed structures (Mo-scaffold) was printed, and its ability to regulate pro-osteogenic and anti-osteoclastogenic cellular responses was evaluated in vitro and in vivo. We found that extracts derived from Mo-scaffold (Mo-extracts) strongly stimulated osteogenic differentiation of bone marrow mesenchymal stem cells and inhibited differentiation of osteoclast progenitors. The identified comodulatory effect was further demonstrated to arise from Mo ions in the Mo-extract, wherein Mo ions suppressed osteoclastic differentiation by scavenging reactive oxygen species (ROS) and inhibiting mitochondrial biogenesis in osteoclasts. Consistent with the in vitro findings, the Mo-scaffold was found to significantly promote osteoblast-mediated bone formation and inhibit osteoclast-mediated bone resorption throughout the bone healing process, leading to enhanced bone regeneration. In combination with our previous finding that Mo ions participate in material-mediated immunomodulation, this study offers the new insight that Mo ions facilitate bone repair by comodulating the balance between bone formation and resorption. Our findings suggest that Mo ions are multifunctional cellular modulators that can potentially be used in biomaterial design and bone tissue engineering.
