Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies.
10.1038/s41368-022-00187-z
- Author:
Yuangang WU
1
;
Jiao LI
2
;
Yi ZENG
1
;
Wenchen PU
2
;
Xiaoyu MU
2
;
Kaibo SUN
1
;
Yong PENG
3
;
Bin SHEN
4
Author Information
1. Orthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.
2. Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
3. Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China. yongpeng@scu.edu.cn.
4. Orthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China. shenbin_1971@163.com.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Apoptosis;
Cartilage/pathology*;
Cartilage, Articular/metabolism*;
Cell Communication;
Chondrocytes/metabolism*;
Exosomes/pathology*;
Humans;
Osteoarthritis/therapy*
- From:
International Journal of Oral Science
2022;14(1):40-40
- CountryChina
- Language:English
-
Abstract:
Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage loss and accounts for a major source of pain and disability worldwide. However, effective strategies for cartilage repair are lacking, and patients with advanced OA usually need joint replacement. Better comprehending OA pathogenesis may lead to transformative therapeutics. Recently studies have reported that exosomes act as a new means of cell-to-cell communication by delivering multiple bioactive molecules to create a particular microenvironment that tunes cartilage behavior. Specifically, exosome cargos, such as noncoding RNAs (ncRNAs) and proteins, play a crucial role in OA progression by regulating the proliferation, apoptosis, autophagy, and inflammatory response of joint cells, rendering them promising candidates for OA monitoring and treatment. This review systematically summarizes the current insight regarding the biogenesis and function of exosomes and their potential as therapeutic tools targeting cell-to-cell communication in OA, suggesting new realms to improve OA management.
