Fever Associated with Clozapine Administration: Incidence, Clinical Characteristics, and Related Factors.
- Author:
Hee Jung NAM
1
;
Hyun Ok JEON
;
Se Chang YOON
;
Dongsoo LEE
;
Kyung Sue HONG
Author Information
1. Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. kshong@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Clozapine-induced fever;
Schizophrenia
- MeSH:
Clozapine*;
Fever*;
Hospital Records;
Humans;
Incidence*;
Inpatients;
Retrospective Studies;
Schizophrenia
- From:Korean Journal of Psychopharmacology
2005;16(3):234-239
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study aims at investigating the incidence, clinical nature and associated clinical characteristics of the clozapine-induced fever. METHODS: Retrospective review of hospital records was performed for 56 inpatients who had started to take clozapine and stayed at the hospital for four or more weeks after the initiation of clozapine treatment. RESULTS AND CONCLUSION: Clozapine-induced fever was developed in 31% of the patients. The mean peak temperature was 39degrees C and the mean duration of the fever was 3 days. Fever was developed average of 11 days after the initiation of clozapine treatment. All the patients were recovered without discontinuation of clozapine. Demographic variables, the clinical response to clozapine, other drugs administered with clozapine, and the presence of other adverse effects of clozapine were not associated with the clozapine-induced fever.
