Reading-related Brain Function Restored to Normal After Articulation Training in Patients with Cleft Lip and Palate: An fMRI Study.
10.1007/s12264-022-00918-6
- Author:
Liwei SUN
1
;
Wenjing ZHANG
2
;
Mengyue WANG
3
;
Songjian WANG
4
;
Zhen LI
5
;
Cui ZHAO
1
;
Meng LIN
6
;
Qian SI
1
;
Xia LI
1
;
Ying LIANG
1
;
Jing WEI
1
;
Xu ZHANG
7
;
Renji CHEN
8
;
Chunlin LI
9
Author Information
1. School of Biomedical Engineering, Capital Medical University, Beijing, 100069, China.
2. Beijing Stomatological Hospital, Capital Medical University, Beijing, 100050, China.
3. School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
4. Beijing Institute of Otolaryngology-Head and Neck Surgery, Beijing, 100005, China.
5. Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, China.
6. Peking University First Hospital, Beijing, 100034, China.
7. School of Biomedical Engineering, Capital Medical University, Beijing, 100069, China. zhangxu@ccmu.edu.cn.
8. Beijing Stomatological Hospital, Capital Medical University, Beijing, 100050, China. chenrenji@126.com.
9. School of Biomedical Engineering, Capital Medical University, Beijing, 100069, China. lichunlin1981@163.com.
- Publication Type:Journal Article
- Keywords:
Articulation training;
Functional connectivity;
Graph-based network analysis;
Non-syndromic cleft lip and palate;
fMRI
- MeSH:
Brain/diagnostic imaging*;
Cleft Lip/surgery*;
Cleft Palate/surgery*;
Humans;
Magnetic Resonance Imaging;
Reading
- From:
Neuroscience Bulletin
2022;38(10):1215-1228
- CountryChina
- Language:English
-
Abstract:
Cleft lip and/or palate (CLP) are the most common craniofacial malformations in humans. Speech problems often persist even after cleft repair, such that follow-up articulation training is usually required. However, the neural mechanism behind effective articulation training remains largely unknown. We used fMRI to investigate the differences in brain activation, functional connectivity, and effective connectivity across CLP patients with and without articulation training and matched normal participants. We found that training promoted task-related brain activation among the articulation-related brain networks, as well as the global attributes and nodal efficiency in the functional-connectivity-based graph of the network. Our results reveal the neural correlates of effective articulation training in CLP patients, and this could contribute to the future improvement of the post-repair articulation training program.
