Progress in Modeling Neural Tube Development and Defects by Organoid Reconstruction.
10.1007/s12264-022-00896-9
- Author:
Peng LI
1
;
Yongchang CHEN
2
Author Information
1. State Key Laboratory of Primate Biomedical Research and Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, China.
2. State Key Laboratory of Primate Biomedical Research and Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, China. chenyc@lpbr.cn.
- Publication Type:Review
- Keywords:
Neural tube;
Neural tube defect;
Organoid
- MeSH:
Humans;
Organoids;
Neural Tube;
Neurodevelopmental Disorders/genetics*;
Brain;
Alzheimer Disease
- From:
Neuroscience Bulletin
2022;38(11):1409-1419
- CountryChina
- Language:English
-
Abstract:
It is clear that organoids are useful for studying the structure as well as the functions of organs and tissues; they are able to simulate cell-to-cell interactions, symmetrical and asymmetric division, proliferation, and migration of different cell groups. Some progress has been made using brain organoids to elucidate the genetic basis of certain neurodevelopmental disorders. Such as Parkinson's disease and Alzheimer's disease. However, research on organoids in early neural development has received insufficient attention, especially that focusing on neural tube precursors. In this review, we focus on the recent research progress on neural tube organoids and discuss both their challenges and potential solutions.
