Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns.

Lei QU; Xinyu HE; Qian Tang; Xiao Fan; Jian Liu; Aifu Lin

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Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns.

Author: Lei QU ¹ ; Xinyu HE ¹ ; Qian TANG ² ; Xiao FAN ¹ ; Jian LIU ³ ; Aifu LIN ⁴
Author Information

1. MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
2. Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining 314400, China.
3. Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining 314400, China. jianl@intl.zju.edu.cn.
4. MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou 310058, China. linaifu@zju.edu.cn.
Publication Type:Review
Keywords: Ferroptosis; Iron metabolism; Long noncoding RNA (lncRNA); Tumorigenesis
MeSH: Fatty Acids, Unsaturated; Ferroptosis; Humans; Iron/therapeutic use*; Neoplasms/metabolism*; RNA, Long Noncoding/genetics*; Trace Elements/therapeutic use*
From: Journal of Zhejiang University. Science. B 2022;23(10):844-862
CountryChina
Language:English
Abstract: Cancer cells undergo substantial metabolic alterations to sustain increased energy supply and uncontrolled proliferation. As an essential trace element, iron is vital for many biological processes. Evidence has revealed that cancer cells deploy various mechanisms to elevate the cellular iron concentration to accelerate proliferation. Ferroptosis, a form of cell death caused by iron-catalyzed excessive peroxidation of polyunsaturated fatty acids (PUFAs), is a promising therapeutic target for therapy-resistant cancers. Previous studies have reported that long noncoding RNA (lncRNA) is a group of critical regulators involved in modulating cell metabolism, proliferation, apoptosis, and ferroptosis. In this review, we summarize the associations among iron metabolism, ferroptosis, and ferroptosis-related lncRNA in tumorigenesis. This information will help deepen understanding of the role of lncRNA in iron metabolism and raise the possibility of targeting lncRNA and ferroptosis in cancer combination therapy.