Application of mesenchymal stem cells in tumor therapy.
10.11817/j.issn.1672-7347.2022.220116
- Author:
Xiangling TANG
1
;
Yu ZHANG
2
;
Xionghao LIU
3
;
Mujun LIU
4
Author Information
1. Genetics Laboratory, College of Life Science, Central South University, Changsha 410078. tangxiangling@sklmg.edu.cn.
2. Genetics Laboratory, College of Life Science, Central South University, Changsha 410078.
3. Hunan Key Laboratory of Medical Genetics, Changsha 410078.
4. Hunan Key Laboratory of Basic and Applied Hematology, Changsha 410008, China. liumujun03@csu.ed.cn.
- Publication Type:Journal Article
- Keywords:
combination therapy;
extracellular vesicles;
genetic modification;
mesenchymal stem cells;
tumor treatment
- MeSH:
Humans;
Mesenchymal Stem Cell Transplantation;
Mesenchymal Stem Cells
- From:
Journal of Central South University(Medical Sciences)
2022;47(10):1444-1453
- CountryChina
- Language:English
-
Abstract:
Mesenchymal stem cells (MSCs) are multipotent stem cells that exist widely in the human body, which can self-renewal and differentiate into different types of cell. Due to its advantages of tumor tissue tropism and easy to be engineered, it has been widely used in cancer treatment research recently. However, the tumor-promoting or anti-tumor effect of MSCs is controversial, especially for unmodified MSCs. Therefore, researchers are more inclined to use MSCs as carriers to engineer them. With the deepening in understanding of vesicles, it is found that the vesicles derived from MSCs seem to have greater advantages as carriers. Although the current research of MSCs in the treatment of tumors has been initiated in the clinic, there are still many problems to be solved in the pre-clinical application.
