Bone Mineral Density and Bone Markers in the Children with Epilepsy Taking on Chronic Anticonvulsants.
- Author:
Soon Bum LEE
1
;
So Young KANG
;
Jeesuk YU
Author Information
1. Department of Pediatrics, College of Medicine, Dankook University, Cheonan, Korea. dryujs@dankook.ac.kr
- Publication Type:Original Article
- Keywords:
Bone mineral density;
Bone markers;
Child;
Epilepsy;
Anticonvulsants
- MeSH:
Absorptiometry, Photon;
Alkaline Phosphatase;
Anticonvulsants*;
Biomarkers;
Body Mass Index;
Bone Density*;
Calcium;
Cerebral Palsy;
Child*;
Chronic Disease;
Cohort Studies;
Encephalomalacia;
Epilepsy*;
Female;
Heart Septal Defects, Atrial;
Humans;
Hypocalcemia;
Metabolism;
Microcephaly;
Parathyroid Hormone;
Population Characteristics;
Spine
- From:Korean Journal of Pediatrics
2005;48(5):527-533
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Long-term administration of anticonvulsants in children with epilepsy may cause short stature, hypocalcemia and low bone mineral density. This study was performed for the early detection of abnormal bone metabolism in children with epilepsy on taking anticonvulsants. METHODS: Thirty children aged 5 to 16 years who were diagnosed with epilepsy were enrolled in this study. All had taken anticonvulsants for more than one year. Bone mineral density of lumbar vertebra was measured by dual-energy X-ray absorptiometry. Serum calcium, phosphorous, alkaline phosphatase, 25-hydroxycholecalciferol[25(OH)D3], parathyroid hormone, and urine deoxypyridinoline were measured as biochemical bone markers. Bone age and body mass index were also calculated. RESULTS: Bone minreal density, body mass index, bone age, and height were significantly decreased in two female patients who had taken two antiepileptic drugs for more than four years and they also had chronic diseases such as cerebral palsy with microcephaly, encephalomalacia, and microcephaly with atrial septal defect. Bone mineral density had significant positive correlations with body mass index(P<0.01) and bone age(P<0.01). CONCLUSION: This study showed chronic medication of anticonvulsants in children may cause low bone mineral density and short stature. Bone age and body mass index could be the important surrogate markers to find the population at risk. More studies, including a large study population and long term cohort study, will be required.
