Enhancement of Swimming Endurance by Herbal Supplement M3P.
10.1007/s11655-021-3502-7
- Author:
Chien-Ming CHU
1
;
Chih-Wen CHI
2
;
Chih-Hung HUANG
1
;
Yu-Jen CHEN
3
Author Information
1. Graduate Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, Taipei, Taiwan, 10608, China.
2. Department of Medical Research, MacKay Memorial Hospital, New Taipei City, Taiwan, 25160, China.
3. Department of Medical Research, MacKay Memorial Hospital, New Taipei City, Taiwan, 25160, China. chenmdphd@gmail.com.
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
M3P;
fatigue;
mice;
replenishing qi and nourishing blood;
swimming endurance;
tonifying Kidndy (Shen) and invigorating Spleen (Pi)
- MeSH:
Animals;
Body Weight;
Deer;
Dietary Supplements;
Fatigue/drug therapy*;
Hydrocortisone;
Liver Glycogen;
Male;
Mice;
Mice, Inbred ICR;
Muscle, Skeletal;
Swimming/physiology*
- From:
Chinese journal of integrative medicine
2022;28(8):725-729
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To investigate the effect of M3P (containing Deer antler, Cordyceps sinensis, Rhodiola rosea, and Panax ginseng); an herbal remedy with the function of tonifying Kidney (Shen) and invigorating Spleen (Pi), replenishing qi and nourishing blood; on fatigue alleviation, endurance capacity and toxicity.
METHODS:Swimming with weight-loading of 24 male ICR mice was used to evaluate the endurance capacity, and fatigue-related plasma biomarkers were determined. Mice were randomly assigned to control or M3P treatment groups with 6 mice for each group and were orally administered with M3P everyday for 8 weeks at doses 0, 10, 33 or 100 mg/kg. Swimming time to exhaustion was measured in a specialized water tank. Lliver and kidney functions, body weight, and hematological profile were determined to evaluate the safety and toxicity after long-term M3P administration.
RESULTS:M3P supplementation 100 mg/kg significantly increased swimming endurance time up to approximate 2.4 folds of controls (P<0.05). The plasma concentrations of cortisol and hepatic glycogen content were significantly increased in mice received M3P (P<0.05, P<0.01 respectively). The lactic acid level and blood glucose were not changed after M3P treatment (P>0.05). The liver and kidney functions muscle damage biomarker creatine, body weight, and hemograms were not altered in M3P supplementation (P>0.05).
CONCLUSION:M3P supplementation may improve swimming endurance accompanied by increasing hepatic glycogen content and serum cortisol level without major toxicity.
