Association of CDH1, FANCB and APC Gene Polymorphisms
with Lung Cancer Susceptibility in Chinese Population.
10.3779/j.issn.1009-3419.2022.102.21
- Author:
Lianchun SU
1
;
Hua HUANG
2
;
Min GAO
3
;
Yongwen LI
4
;
Ruifeng SHI
2
;
Chen CHEN
4
;
Xuanguang LI
2
;
Guangsheng ZHU
2
;
Hongyu LIU
4
;
Jun CHEN
1
Author Information
1. Department of Thoracic Surgery, First Affiliated Hospital of Medical College, Shihezi University, Shihezi 832002, China.
2. Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
3. Department of Thoracic Surgery, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China.
4. Tianjin Key Laboratory of
Lung Cancer, Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute,
Tianjin Medical University General Hospital, Tianjin 300052, China.
- Publication Type:Journal Article
- Keywords:
APC;
CDH1;
FANCB;
Lung neoplasms;
Single nucleotide polymorphism;
Susceptibility
- MeSH:
Antigens, CD/genetics*;
Cadherins/genetics*;
Case-Control Studies;
China;
Fanconi Anemia Complementation Group Proteins/genetics*;
Gene Frequency;
Genes, APC;
Genetic Predisposition to Disease;
Genotype;
Humans;
Lung Neoplasms/genetics*;
Polymorphism, Single Nucleotide
- From:
Chinese Journal of Lung Cancer
2022;25(9):658-664
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Lung cancer is the main cause of cancer-related death globally. Single nucleotide polymorphism (SNP) is one of the important factors leading to the occurrence of lung cancer, but its mechanism has not been elucidated. This study intends to investigate the relationship between SNPs of CDH1, FANCB, APC genes and lung cancer genetic susceptibility.
METHODS:The case-control study design was used. We collected blood samples from 270 lung cancer cases in the Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, as well as blood samples from 445 healthy volunteers as controls, and extracted genomic DNA for genotyping using the Taqman® SNP genotyping kit. The distribution of three SNP loci of CDH1 gene rs201141645, FANCB gene rs754552650 and APC gene rs149353082 in Chinese population was analyzed. Chi-square test and Logistic regression were used to analyze the relationship between different genotypes and the risk of lung cancer.
RESULTS:The distribution frequencies of AA, A/G and GG genotypes at rs754552650 of FANCB gene in the control group were 27.2%, 52.6% and 20.2%, respectively. The distribution frequencies of AA and A/G genotypes were 93.7% and 6.3% in the case group, respectively, and no GG genotype was detected. The A/G genotype of the rs754552650 locus of the FANCB gene was significantly different between the case group and the control group. Compared with the carriers of AA genotype, the individuals with FANCB rs754552650 A/G genotype had a lower risk of lung cancer (OR=0.035, 95%CI: 0.020-0.062, P<0.001). CDH1 gene rs201141645 A/C and CC genotypes only existed in the control group. In addition, only 1 sample was found to have APC rs149353082 genotype in the case group.
CONCLUSIONS:In the Chinese population, the lung cancer risk of the individuals with FANCB rs754552650 A/G genotype was significantly decreased.
